Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hexamethylenetetramine → 5-Formylthiophene-2-Carbonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hexamethylenetetramine | HCID 4101 | — |
| 반응물 | N-bromobutanimide | HCID 67184 | — |
| 반응물 | 5-Methylthiophene-2-carbonitrile | HCID 312733 | — |
| 반응물 | 5-(Bromomethyl)thiophene-2-carbonitrile | HCID 10560016 | — |
| 촉매 | Benzoyl Peroxide | HCID 7187 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Carbon Tetrachloride | HCID 5943 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | 5-Formylthiophene-2-Carbonitrile | HCID 12280004 | 44.8% |
반응 단계
8 g of 5-bromomethylthiophene-2-carbonitrile (prepared by brominating 5.7 g of 5-methylthiophene-2-carbonitrile and 8.42 g of N-bromosuccinimide in 68 ml of carbon tetrachloride under exposure to light and with the addition of 185 mg of benzoyl peroxide) is refluxed for 30 minutes in 35 ml of chloroform with 5.6 g of hexamethylenetetramine. The precipitated salt is suctioned off and refluxed in 30 ml of acetic acid and 30 ml of water for 2 hours. After extraction with ether, washing of the ether phase with water, drying, and evaporation, 2.43 g of 5-cyanothiophene-2-aldehyde is obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05280035 |
| 출처 데이터셋 | uspto-grants-1994_01 |
| ORD ID | ord-d1535dd1bad849a983af595cdf90a1c0 |
| 출처 메모 | uspto-grants-1994_01 |