Benzoylacetone → 2Z-[(4-hexylphenyl)methylene]-1-phenyl-1,3-butanedione

HRID 1198214

반응식

HRID 1198214 반응식
[C:1]([CH2:9][C:10](=[O:12])[CH3:11])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:13]([C:19]1[CH:26]=[CH:25][C:22]([CH:23]=O)=[CH:21][CH:20]=1)[CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]>N1CCCCC1.C(OCC)C>[CH2:13]([C:19]1[CH:26]=[CH:25][C:22](/[CH:23]=[C:9](/[C:10](=[O:12])[CH3:11])\[C:1]([C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[O:8])=[CH:21][CH:20]=1)[CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]

참가 물질

5

반응물 2

HCID 7166Benzoylacetone2회HCID 170813Benzaldehyde, 4-hexyl-

생성물 1

HCID 678204432Z-[(4-hexylphenyl)methylene]-1-phenyl-1,3-butanedione

시약·촉매·용매 2

HCID 8082Piperidine촉매HCID 3283Diethyl Ether용매

실험 절차

Benzoylacetone (0.65g, 0.004 moles), parahexylbenzaldehyde (0.76g, 0.004 moles) and piperidine (3 drops) were stirred in ethyl ether (10ml) for 20 hrs. An additional 200mg benzoylacetone was added and the solution stirred for 48 hrs. The solution was concentrated to an oil with a gentle stream of Nitrogen. The product was purified by silica gel chromatography. The structure assignment was supported by NMR, infrared and uv spectra and elemental analysis (334.5).

후처리

  1. concentrationThe solution was concentrated to an oil with a gentle stream of Nitrogen
  2. customThe product was purified by silica gel chromatography

출처 및 근거

ORD 기록
ord-534fa26faf7540c49b873a3ed7cde52c
출처 데이터셋
uspto-grants-1994_01
특허 번호
US05280047

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