Potassium Carbonate → HCID 178442094, 화합물

HRID 1198328

반응식

HRID 1198328 반응식
[CH2:1]([C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[CH:16][C:15]([OH:18])=[C:14]([F:19])[C:13]=2[F:20])=[CH:8][CH:7]=1)[CH2:2][CH2:3][CH2:4][CH3:5].[CH2:21]([C@H:26]1[CH2:31][CH2:30][C@H:29]([CH2:32]I)[CH2:28][CH2:27]1)[CH2:22][CH2:23][CH2:24][CH3:25].C([O-])([O-])=O.[K+].[K+]>CN(C)C=O>[CH2:1]([C:6]1[CH:7]=[CH:8][C:9]([C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:32][C@H:29]3[CH2:30][CH2:31][C@H:26]([CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])[CH2:27][CH2:28]3)=[C:14]([F:19])[C:13]=2[F:20])=[CH:10][CH:11]=1)[CH2:2][CH2:3][CH2:4][CH3:5]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 191036434'-Pentyl-2,3-difluorobiphenyl-4-olHCID 178444521HCID 178444521, 화합물

생성물 1

HCID 178442094HCID 178442094, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

0.1 mol of 4'-n-pentyl-2,3-difluorobiphenyl-4-ol and 0.1 mol of trans-4-n-pentylcyclohexylmethyl iodide and heated in the presence of 0.12 mol of anhydrous K2CO3 in dimethylformamide (DMF) until the mixture boils gently. When the reaction has ended, the mixture is worked up in the customary manner and the product is purified by chromatography and crystallization. Trans-4-n-pentylcyclohexylmethyl 4'-pentyl-2,3-difluorobiphenyl-4-yl ether is obtained.

후처리

  1. customthe product is purified by chromatography and crystallization

출처 및 근거

ORD 기록
ord-45da8cae7649494cbef17b87fd5a88e3
출처 데이터셋
uspto-grants-1994_01
특허 번호
US05279764

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