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Triethylamine → 4-[(4-Ethoxy-2,3-difluorophenyl)ethynyl]-4'-propyl-1,1'-biphenyl

HRID 1198335
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HRID 1198335 반응식
BrBr.[CH2:3]([O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]([C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:25]=[CH:24]C(CCC)=CC=3)=CC=2)=C)=[C:8]([F:29])[C:7]=1[F:30])[CH3:4].C(N([CH2:36][CH3:37])CC)C.C([N-][CH:42]([CH3:44])[CH3:43])(C)C.[Li+]>ClCCl.C(#N)C.C1COCC1>[CH2:3]([O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]#[C:14][C:19]2[CH:18]=[CH:17][C:20]([C:37]3[CH:36]=[CH:8][C:7]([CH2:44][CH2:42][CH3:43])=[CH:6][CH:11]=3)=[CH:25][CH:24]=2)=[C:8]([F:29])[C:7]=1[F:30])[CH3:4]
참가 물질실험 절차출처 및 근거반응 노트

참가 물질

8

반응물 4

HCID 8471TriethylamineHCID 24408BromineHCID 2724682Lithium diisopropylamideHCID 19103502HCID 19103502, 화합물

생성물 1

HCID 678645704-[(4-Ethoxy-2,3-difluorophenyl)ethynyl]-4'-propyl-1,1'-biphenyl

시약·촉매·용매 3

HCID 6342Acetonitrile용매
HCID 6344
Dichloromethane
용매
HCID 8028Tetrahydrofuran용매2회

실험 절차

0.065 mol of bromine are added to a stirred solution of 0.065 mol of this ethen derivative in a mixture of 100 ml of dichloromethane and 50 ml of acetonitrile. After addition of 10 g of triethylamine and customary working up the crude product is dissolved in 50 ml of THF. 0.13 mol of lithium diisopropylamide in 120 ml of THF are added dropwise to this solution at -50° C. Customary working up gives 1-(4-Ethoxy-2,3-difluorophenyl)-2-(4'-propylbiphenyl-4-yl)-ethine.

출처 및 근거

ORD 기록
ord-60e7d7fecfa248db9756eefc78bf9e50
출처 데이터셋
uspto-grants-1994_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05279764

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