Water → HCID 178441853, 화합물

HRID 1198482노트

반응식

HRID 1198482 반응식
[CH2:1]([C:5]1[NH:6][C:7]2[C:12]([C:13](=[O:15])[N:14]=1)=[CH:11][C:10](I)=[CH:9][CH:8]=2)[CH2:2][CH2:3][CH3:4].[Cu][C:18]#[N:19].O>N1C=CC=CC=1>[CH2:1]([C:5]1[NH:6][C:7]2[C:12]([C:13](=[O:15])[N:14]=1)=[CH:11][C:10]([C:18]#[N:19])=[CH:9][CH:8]=2)[CH2:2][CH2:3][CH3:4]

참가 물질

5

반응물 3

HCID 962WaterHCID 178418546HCID 178418546, 화합물HCID 178441862HCID 178441862, 화합물

생성물 1

HCID 178441853HCID 178441853, 화합물수율 72.2%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

A mixture of 6.4 g of 2-butyl-6-iodo-4(1H)-quinazolinone in 25 ml of pyridine is added 3.6 g of copper(I) cyanide followed by heating at reflux for 16 hours. The reaction mixture is poured into water and stirred at room temperature for 8 hours. The suspension is filtered and the cake washed well with water and air dried. The solid is dissolved in 3:1 chloroform-methanol and dried with MgSO4. The volatiles are evaporated in vacuo to give 3.2 g of the desired product as a solid. m.p. 243°-45° C.

후처리

  1. temperatureby heating
  2. temperatureat reflux for 16 hours
  3. filtrationThe suspension is filtered
  4. washthe cake washed well with water and air
  5. customdried
  6. dissolutionThe solid is dissolved in 3:1 chloroform-methanol
  7. dry with materialdried with MgSO4
  8. customThe volatiles are evaporated in vacuo

출처 및 근거

ORD 기록
ord-66ca6f44ce0b4c5a8dbd1084a5d79e51
출처 데이터셋
uspto-grants-1994_01
특허 번호
US05281603

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