Thionyl Chloride → HCID 13772860, 화합물

HRID 1198602노트

반응식

HRID 1198602 반응식
[C:1]1([CH:7]([N:9]2[CH2:13][CH2:12][CH:11]([CH2:14]O)[CH2:10]2)[CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.S(Cl)([Cl:18])=O>ClCCCl>[Cl:18][CH2:14][CH:11]1[CH2:12][CH2:13][N:9]([CH:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH3:8])[CH2:10]1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 13772857HCID 13772857, 화합물

생성물 1

HCID 13772860HCID 13772860, 화합물수율 100%

시약·촉매·용매 1

HCID 111,2-Dichloroethane용매

실험 절차

A solution of 0.50 g (2.44 mmol) [3R-(R*,R*)]-(1-phenylethyl)-3-pyrrolidinemethanol in 5 mL 1,2-dichloroethane was treated with 2 mL thionyl chloride, refluxed two hours, evaporated, and crystallized by trituration with ether to afford 0.64 g (100%) of the title compound as the hydrochloride, mp 140°-146° C., [α]D +27.8° C. (c, 1.07, methanol).

후처리

  1. temperaturerefluxed two hours
  2. customevaporated
  3. customcrystallized by trituration with ether

출처 및 근거

ORD 기록
ord-9d9a5eeef6d34c06a9280975ad8eae03
출처 데이터셋
uspto-grants-1994_01
특허 번호
US05281612

반응 노트

불러오는 중…