참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 4-Bromobenzyl alcohol | HCID 70119 | — |
| 반응물 | (2-(N-(tert-Butyl)sulfamoyl)-5-propylphenyl)boronic acid | HCID 19939476 | — |
| 촉매 | HCID 178418397 | HCID 178418397 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | [2'-(N-t-Butylsulfamoyl)-5'n-propylbiphenyl-4-yl]methanol | HCID 19939403 | — |
반응 단계
To a solution of 2.80 g (9.36 mmol ) of 2-(N-t-butylsulfamoyl)-5-n-propylphenylboronic acid (from Step B) and 4-bromobenzyl alcohol (5.25 g, 3 equiv) in toluene (125 mL) was added 1.25N NaOH (32 mL), EtOH (86 mL) and tetrakis(triphenylphosphine)palladium(0) (325 mg, 3 mol %). The mixture was stirred at 100° C. under N2 for 3 hours. The reaction was concentrated and the residue was extracted with ethyl acetate. The organic solution was washed with 1N NaOH, H2O and brine. Next, the organic phase was dried over anhydrous MgSO4 and concentrated in vacuo. The product was purified by flash chromatography, eluting with 2:1 hexane-EtOAc, to provide the titled compound; Rf =0.42 (1:1 EtOAc-hexane).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US05281614 |
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| 출처 데이터셋 | uspto-grants-1994_01 |
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| ORD ID | ord-9d06ee2337644cecb891377474571fe1 |
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| 출처 메모 | uspto-grants-1994_01 |
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