(Methoxymethyl)triphenylphosphonium bromide → 1-(2-Methoxyethenyl)-4-(1-methylbutyloxy)benzene

HRID 1198717노트

반응식

HRID 1198717 반응식
C([Li])CCC.[Br-].[CH3:7][O:8][CH2:9][P+](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.[CH3:29][CH:30]([O:34][C:35]1[CH:42]=[CH:41][C:38]([CH:39]=O)=[CH:37][CH:36]=1)[CH2:31][CH2:32][CH3:33]>CCCCCC.O1CCCC1>[CH3:7][O:8][CH:9]=[CH:39][C:38]1[CH:41]=[CH:42][C:35]([O:34][CH:30]([CH3:29])[CH2:31][CH2:32][CH3:33])=[CH:36][CH:37]=1

참가 물질

6

반응물 3

HCID 2773654(Methoxymethyl)triphenylphosphonium bromideHCID 199306244-(1-Methylbutyloxy)benzaldehydeHCID 178418339Butyllithium

생성물 1

HCID 537267651-(2-Methoxyethenyl)-4-(1-methylbutyloxy)benzene

시약·촉매·용매 2

HCID 8028Tetrahydrofuran용매2회HCID 8058Hexane용매

실험 절차

A solution containing butyllithium dissolved in hexane was added to a solution containing 120 g of methoxymethyltriphenylphosphonium bromide dissolved in tetrahydrofuran (THF), in an atmosphere of argon, and the mixture was stirred for one hour at room temperature. A solution of the compound (30) dissolved in THF was added thereto and stirring was continued for two hours. The reaction solution was washed with water, was dried over magnesium sulfate, and was then concentrated. The residue was purified by column chromatography to obtain 1-(2-methoxyethenyl)-4-(1-methylbutyloxy)benzene (31).

후처리

  1. additionwas added to a solution
  2. additionwas added
  3. stirringstirring
  4. waitwas continued for two hours
  5. washThe reaction solution was washed with water
  6. dry with materialwas dried over magnesium sulfate
  7. concentrationwas then concentrated
  8. customThe residue was purified by column chromatography

출처 및 근거

ORD 기록
ord-9823642ffc3c453189b6682e84aa9eea
출처 데이터셋
uspto-grants-1994_01
특허 번호
US05281685

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