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Water → HCID 178443563, 화합물

HRID 1198846
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HRID 1198846 반응식
[CH:1]([N:4]1[CH2:9][CH2:8][CH2:7][CH2:6][CH2:5]1)=[CH:2][CH3:3].C(N(CC)CC)C.[CH2:17]([C@H:24]1[CH2:29][CH2:28][C@H:27]([C:30](=[O:34])[CH:31]=[CH:32]Cl)[CH2:26][CH2:25]1)[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23].O>C(OCC)C>[CH2:17]([C@H:24]1[CH2:29][CH2:28][C@H:27]([C:30](=[O:34])[CH:31]=[CH:32][C:2]([CH3:3])=[CH:1][N:4]2[CH2:9][CH2:8][CH2:7][CH2:6][CH2:5]2)[CH2:26][CH2:25]1)[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23]
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참가 물질

6

반응물 4

HCID 962WaterHCID 8471TriethylamineHCID 138954N-(1-propenyl)piperidineHCID 178443564HCID 178443564, 화합물

생성물 1

HCID 178443563HCID 178443563, 화합물

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

A mixture of 6 g of N-(1-propenyl)piperidine, 45 ml of of diethyl ether and 4.36 ml of triethylamine is treated dropwise while stirring and gassing with nitrogen at 0° C. within 1 hour with a solution of 8.5 g of trans-4-heptyl-1-(3-chloroacryloyl)cyclohexane in 20 ml of diethyl ether. The suspension is stirred at 0° C. for a further 1 hour and then treated with 120 ml of water and extracted three times with diethyl ether. The organic phases are washed twice with water, dried over sodium sulphate, filtered and concentrated, there being obtained N-[5-(trans-4-heptylcyclohexyl)-2-methyl-5-oxo-1,3-pentadienyl]piperidine.

후처리

  1. additionis treated dropwise
  2. stirringThe suspension is stirred at 0° C. for a further 1 hour
  3. extractionextracted three times with diethyl ether
  4. washThe organic phases are washed twice with water
  5. dry with materialdried over sodium sulphate
  6. filtrationfiltered
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-5a9dfba4aa674e97aea9d2912f9ab059
출처 데이터셋
uspto-grants-1990_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04898455

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