Sodium Carbonate → 2-methoxy-6[(N-2-nitrophenyl)-amino]-8-methylquinoline

HRID 1198942노트

반응식

HRID 1198942 반응식
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[C:6]([CH3:14])[CH:7]=[C:8]([NH2:13])[CH:9]=2)[N:4]=1.F[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[N+:22]([O-:24])=[O:23].C(=O)([O-])[O-].[Na+].[Na+]>>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[C:6]([CH3:14])[CH:7]=[C:8]([NH:13][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[N+:22]([O-:24])=[O:23])[CH:9]=2)[N:4]=1

참가 물질

4

반응물 3

HCID 10340Sodium CarbonateHCID 738951-Fluoro-2-nitrobenzeneHCID 198670716-Amino-2-methoxy-8-methylquinoline

생성물 1

HCID 198677162-methoxy-6[(N-2-nitrophenyl)-amino]-8-methylquinoline

실험 절차

This compound, m.p. 185°, was prepared similarly to Preparation 20 using 2-methoxy-6-amino-8-methylquinoline, 1-fluoro-2-nitrobenzene, and sodium carbonate as starting materials. The product was characterised spectroscopically and used directly in Preparation 17 without further purification.

후처리

  1. customused directly in Preparation 17 without further purification

출처 및 근거

ORD 기록
ord-39a85318e462431ca299a15576a8cc13
출처 데이터셋
uspto-grants-1990_02
특허 번호
US04898872

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