Hydrogen Peroxide → 3-(4-Chlorophenyl)-7-methyl-2,1-benzisoxazole
반응식
[NH2:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:9]([C:11]1[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=1)=[O:10].OO>C(O)(=O)C>[Cl:17][C:14]1[CH:15]=[CH:16][C:11]([C:9]2[O:10][N:1]=[C:2]3[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=23)=[CH:12][CH:13]=1참가 물질
4
실험 절차
A solution of 49 g (0.2 mole) of (2-amino-3-methylphenyl)(4-chlorophenyl)methanone, 1 liter of glacial acetic acid and 200 ml of 30% hydrogen peroxide was let stand at ambient temperature over the weekend. The mixture was heated on a steam bath for 1 hr and poured into 2.5 liters of ice water. The solid which precipitated was collected by filtration, washed with water, and recrystallized from 2-propanol and then from cyclohexane to yield 16.4 g (34%) of crystals, m.p. 134°-136° C.