Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylformamide → [2-(7-bromo-1,8-naphthyridin-2-yl)-3-oxo-1-isoindolinyl]-N-propylglycolamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 2-chloro-N-propylacetamide | HCID 222357 | — |
| 반응물 | 2-(7-Bromo-1,8-naphthyridin-2-yl)-3-hydroxy-1-isoindolinone | HCID 19900421 | — |
| 생성물 | [2-(7-bromo-1,8-naphthyridin-2-yl)-3-oxo-1-isoindolinyl]-N-propylglycolamide | HCID 19867687 | — |
반응 단계
The procedure is as in Example 26, but starting with 2-(7-bromo-1,8-naphthyridin-2-yl)-3-hydroxy-1-isoindolinone (12 g) in anhydrous dimethylformamide (300 cc), an oily suspension (50% by weight; 2.4 g) of sodium hydride and N-(propyl)chloroacetamide (6.9 g). After recrystallization in acetonitrile, [2-(7-bromo-1,8-naphthyridin-2-yl)-3-oxo-1-isoindolinyl]-N-propylglycolamide (2.1 g), m.p. 174° C., is obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04898871 |
| 출처 데이터셋 | uspto-grants-1990_02 |
| ORD ID | ord-d4f985c2d61648a1ab96336c24aeb34f |
| 출처 메모 | uspto-grants-1990_02 |