Ammonia → 7-amino-2-(2-cyclohexylethyl)-6-nitro-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

HRID 1199104노트

반응식

HRID 1199104 반응식
Cl[C:2]1[N:3]=[C:4]2[S:14][C:13]([CH2:15][CH2:16][CH:17]3[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]3)=[N:12][N:5]2[C:6](=[O:11])[C:7]=1[N+:8]([O-:10])=[O:9].[NH3:23]>C(O)C>[NH2:23][C:2]1[N:3]=[C:4]2[S:14][C:13]([CH2:15][CH2:16][CH:17]3[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]3)=[N:12][N:5]2[C:6](=[O:11])[C:7]=1[N+:8]([O-:10])=[O:9]

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 103153767-chloro-2-(2-cyclohexylethyl)-6-nitro-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

생성물 1

HCID 100875627-amino-2-(2-cyclohexylethyl)-6-nitro-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

In 100 ml of ethanol was suspended 9.59 g of 7-chloro-2-(2-cyclohexylethyl)-6-nitro-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one, and 7 ml of concentrated aqueous ammonia was added thereto at room temperature while stirring. The stirring was continued for 5.5 hours. The precipitate formed was collected by filtration and washed successively with ethanol and diethyl ether to obtain 7.05 g of 7-amino-2-(2-cyclohexylethyl)-6-nitro-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one as a pale yellow crystal.

후처리

  1. additionwas added
  2. customThe precipitate formed
  3. filtrationwas collected by filtration
  4. washwashed successively with ethanol and diethyl ether

출처 및 근거

ORD 기록
ord-32492e2cc2574e199a0a767297e21d7d
출처 데이터셋
uspto-grants-1990_02
특허 번호
US04898943

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