Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → N-[(4,6-Dimethylpyrimidin-2-yl)aminocarbonyl]-3-methyl-2-pyridinesulfonamide-1-oxide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Water | HCID 962 | — |
| 반응물 | 2-Amino-4,6-dimethyl pyrimidine | HCID 13021 | — |
| 반응물 | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| 반응물 | 3-Methylpyridine-2-sulfonamide | HCID 12295469 | — |
| 반응물 | Phenylcarbamate | HCID 21896570 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | N-[(4,6-Dimethylpyrimidin-2-yl)aminocarbonyl]-3-methyl-2-pyridinesulfonamide-1-oxide | HCID 14653190 | — |
반응 단계
To a stirring solution of the N-oxide of 3-methyl-2-pyridinesulfonamide (150 mg, 0.79 mmol) and the phenylcarbamate of 4,6-dimethyl-2-aminopyrimidine (194 mg, 0.79 mmol) in 3 mL of CH3CN was added DBU (121 mg, 0.79 mmol). The solution was stirred for 15 minutes. Three mL of H2O, then 3 mL of 5% HCl was added to the reaction and the resulting solid was collected,d m.p. 161°-163° C. NMR (200 MHz, d6 -DMS0) δ 2,36 (s, 6H), 2.59 (s, 3H), 6.97 (s, 1H), 7.4 (d, 1H), 7.5 (d, 1H), 8.3 (d, 1H), 10.6 (br s, 1H) and 13.3 (br s, 1H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04900353 |
| 출처 데이터셋 | uspto-grants-1990_02 |
| ORD ID | ord-f5f749710f3f412ab04d2b7bc074b7aa |
| 출처 메모 | uspto-grants-1990_02 |