Potassium Carbonate → 5,6-Dimethoxy-2-(5-methoxy-2-nitrophenylthio)-1H-benzimidazole

HRID 1199460

반응식

HRID 1199460 반응식
[CH3:1][O:2][C:3]1[C:12]([O:13][CH3:14])=[CH:11][C:6]2=[N:7][C:8](=[S:10])[N:9]=[C:5]2[CH:4]=1.Cl[C:16]1[CH:21]=[C:20]([O:22][CH3:23])[CH:19]=[CH:18][C:17]=1[N+:24]([O-:26])=[O:25].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH3:1][O:2][C:3]1[C:12]([O:13][CH3:14])=[CH:11][C:6]2[NH:7][C:8]([S:10][C:16]3[CH:21]=[C:20]([O:22][CH3:23])[CH:19]=[CH:18][C:17]=3[N+:24]([O-:26])=[O:25])=[N:9][C:5]=2[CH:4]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 5937892-Chloro-4-methoxy-1-nitrobenzeneHCID 149735355,6-Dimethoxy benzimidazole-2-thione

생성물 1

HCID 198667335,6-Dimethoxy-2-(5-methoxy-2-nitrophenylthio)-1H-benzimidazole

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

5,6-Dimethoxy benzimidazole-2-thione (4.0 g), 2-chloro-4-methoxy nitrobenzene (3.6 g) and potassium carbonate (2.65 g) were stirred together in dry dimethyl formamide (30 ml) at 95° for 3 days. The cooled mixture was poured onto water (300 ml) and the precipitate collected. The solid was washed with water and dried to leave the sub-title compound as a pale yellow solid, MS 361 bp 207.

후처리

  1. additionThe cooled mixture was poured onto water (300 ml)
  2. customthe precipitate collected
  3. washThe solid was washed with water
  4. customdried

출처 및 근거

ORD 기록
ord-474972a81f87497380aaf001ea0a06c6
출처 데이터셋
uspto-grants-1990_02
특허 번호
US04900751

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