2-Aminopyridine → 2-(2-Bromophenyl)imidazo[1,2-a]pyridine

HRID 1199472

반응식

HRID 1199472 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.Br[CH2:9][C:10]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[Br:18])=O>C(O)C>[Br:18][C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=1[C:10]1[N:1]=[C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][N:3]2[CH:9]=1

참가 물질

4

반응물 2

HCID 104392-AminopyridineHCID 27375222-Bromophenacyl Bromide

생성물 1

HCID 28623882-(2-Bromophenyl)imidazo[1,2-a]pyridine

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of 2-aminopyridine (1.63 g) and 2-bromo-1-(2-bromophenyl)-ethanone (4.8 g) in dry ethanol (40 mls) was heated under reflux for 1 hour. The mixture was concentrated in vacuo. The residue was treated with dilute sodium bicarbonate solution and extracted with ethyl acetate. The ethyl acetate was washed with water and brine then dried and evaporated. Flash chromatography produced the sub-title compound as a light grey oil. MS MW 272/274 bp 272.

후처리

  1. temperatureunder reflux for 1 hour
  2. concentrationThe mixture was concentrated in vacuo
  3. additionThe residue was treated with dilute sodium bicarbonate solution
  4. extractionextracted with ethyl acetate
  5. washThe ethyl acetate was washed with water and brine
  6. customthen dried
  7. customevaporated

출처 및 근거

ORD 기록
ord-5dac21755698435cbc12774be3fba360
출처 데이터셋
uspto-grants-1990_02
특허 번호
US04900751

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