N-methyl-2-pyrrolidone → 4-(4-Amino-3-cyano-5-trifluoromethylphenyl)-1,2,4-triazole

반응식

[NH2:1][C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][C:5]([N:12]2[CH:16]=[N:15][N:14]=[CH:13]2)=[CH:4][C:3]=1Br.[CH3:18][N:19]1CCCC1=O>>[NH2:1][C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][C:5]([N:12]2[CH:16]=[N:15][N:14]=[CH:13]2)=[CH:4][C:3]=1[C:18]#[N:19]

참가 물질

반응물 2

HCID 13387N-methyl-2-pyrrolidone

HCID 198670724-(4-Amino-3-bromo-5-trifluoromethylphenyl)-1,2,4-triazole

생성물 1

HCID 198670734-(4-Amino-3-cyano-5-trifluoromethylphenyl)-1,2,4-triazole

실험 절차

The following compound, m.p. 283°, was similarly prepared to the previous Preparation using 4-(4-amino-3-bromo-5-trifluoromethylphenyl)-1,2,4-triazole, cuprous cyanide and 1-methyl-2-pyrrolidone as the starting materials: ##STR148##

후처리

customThe following compound, m.p. 283°, was similarly prepared to the previous Preparation

출처 및 근거

ORD 기록: ord-526bb1d4dba542babcf7c8138c0a5664
출처 데이터셋: uspto-grants-1990_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04900839

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