Potassium Carbonate → Benzene, 1-chloro-4-ethynyl-
반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]#[C:9][Si](C)(C)C)=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+]>CO.CCCCCC>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]#[CH:9])=[CH:4][CH:3]=1참가 물질
5
실험 절차
To a solution of 2(4-chlorophenyl)-1-trimethylsilylethyne Prepared in Stage 1 (30.90g:0.02 mole) in methanol was added potassium carbonate (0.276g:002 mole). The mixture was stirred at room temperature until starting material disappeared as monitored by gas liquid chromatography. After this time, solvent was removed in vacuo and the residue taken up in dichloromethane. The solution was dried and declourised over charcoal. Filtration, followed by removal of solvent gave a brown solid which was passed through silica in hexane. This gave pale yellow crystals (1.511g:55.3%)
후처리
- customAfter this time, solvent was removed in vacuo
- customThe solution was dried
- filtrationFiltration
- customfollowed by removal of solvent
- customgave a brown solid which
출처 및 근거
- ORD 기록
- ord-04cdcb925b3b4ffb92883ea9d746ec49
- 출처 데이터셋
- uspto-grants-1990_02
- 특허 번호
- US04902332
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