HCID 14989639, 화합물 → 5-amino-2-Pyridinepropanoic acid

HRID 1199684노트

반응식

HRID 1199684 반응식
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([CH2:10][CH2:11][C:12]([OH:14])=[O:13])=[N:8][CH:9]=1)([O-])=O>C(O)C.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([CH2:10][CH2:11][C:12]([OH:14])=[O:13])=[N:8][CH:9]=1

참가 물질

4

반응물 1

HCID 14989639HCID 14989639, 화합물

생성물 1

HCID 149896425-amino-2-Pyridinepropanoic acid수율 90%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A solution of 3-(5-nitropyrid-2-yl)propionic acid (4.50 g) in ethanol (140 ml) containing 10% palladium on carbon (0.45 g) was shaken under an atmosphere of hydrogen at 3.4 atmospheres pressure for 1.5 hours. The catalyst was removed by filtration and the filtrate was evaporated to dryness. The residue was recrystallised from acetonitrile to give the title compound (3.43 g) m.p. 118°-120° C.

후처리

  1. customThe catalyst was removed by filtration
  2. customthe filtrate was evaporated to dryness
  3. customThe residue was recrystallised from acetonitrile

출처 및 근거

ORD 기록
ord-74ca1669f53f4947a3f1e81b6b1cd7ba
출처 데이터셋
uspto-grants-1990_02
특허 번호
US04902698

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