5-Aminoimidazole-4-carboxamide hydrochloride → 4-(3,4-Dichlorophenyl)imidazo[1,5-a]pyrimidine-8-carboxamide

HRID 1199949

반응식

HRID 1199949 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([C:9](=O)[CH:10]=[CH:11][N:12]([CH3:14])C)[CH:5]=[CH:6][C:7]=1[Cl:8].Cl.NC1[N:19]=[CH:20][NH:21][C:22]=1[C:23]([NH2:25])=[O:24]>C(O)(=O)C>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:19]3[CH:20]=[N:21][C:22]([C:23]([NH2:25])=[O:24])=[C:14]3[N:12]=[CH:11][CH:10]=2)[CH:5]=[CH:6][C:7]=1[Cl:8]

참가 물질

4

반응물 2

HCID 661465-Aminoimidazole-4-carboxamide hydrochlorideHCID 28051561-(3,4-Dichlorophenyl)-3-(dimethylamino)prop-2-en-1-one

생성물 1

HCID 146774784-(3,4-Dichlorophenyl)imidazo[1,5-a]pyrimidine-8-carboxamide수율 49.6%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A stirred mixture of 12.0 g of 3',4'-dichloro-3-dimethylaminoacrylophenone (prepared as described in Example 9) and 6.3 g of 4-amino-5-imidazolecarboxamide hydrochloride in 450 ml of glacial acetic acid was heated at reflux for 24 hours. The reaction mixture was allowed to stand at room temperature for 16 hours then the mixture was filtered and the crystals that were collected were washed with 300 ml of saturated sodium bicarbonate and then were washed with water. This material was dried, washed with hot methanol and filtered to give 5.9 g of the desired product as yellow crystals, mp 302°-304° C.

후처리

  1. temperaturewas heated
  2. temperatureat reflux for 24 hours
  3. filtrationthe mixture was filtered
  4. customthe crystals that were collected
  5. washwere washed with 300 ml of saturated sodium bicarbonate
  6. washwere washed with water
  7. customThis material was dried
  8. washwashed with hot methanol
  9. filtrationfiltered

출처 및 근거

ORD 기록
ord-0cddb427d58148fa98f48d757f72a635
출처 데이터셋
uspto-grants-1990_02
특허 번호
US04904658

연결된 노트

불러오는 중…