HCID 15588103, 화합물 → Methyl 4-chloro-3-hydroxythiophene-2-carboxylate
반응식
Cl[C:2]1([C:9]([O:11][CH3:12])=[O:10])[C:6](=[O:7])[C:5]([Cl:8])=[CH:4][S:3]1>C(O)(=O)C.[Zn]>[Cl:8][C:5]1[C:6]([OH:7])=[C:2]([C:9]([O:11][CH3:12])=[O:10])[S:3][CH:4]=1참가 물질
4
실험 절차
2,4-Dichloro-2-methoxycarbonylthiophene-3(2H)-one (60 mmol) in acetic acid (50 ml) was treated with metallic zinc (60 mmol) at room temperature for 18 hours. The solvent was removed under reduced pressure and the residue partitioned between water and ether. The organic phase was washed with water, dried with sodium sulphate and the solvent removed under reduced pressure to leave a solid which was crystallised from hexane m.p. 76°-77° C.
후처리
- customThe solvent was removed under reduced pressure
- customthe residue partitioned between water and ether
- washThe organic phase was washed with water
- dry with materialdried with sodium sulphate
- customthe solvent removed under reduced pressure
- customto leave a solid which
- customwas crystallised from hexane m.p. 76°-77° C.
출처 및 근거
- ORD 기록
- ord-90b2f277360440e4b238740d48925f0d
- 출처 데이터셋
- uspto-grants-1990_02
- 특허 번호
- US04904686
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