Water → HCID 14650455, 화합물

HRID 1200194노트

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HRID 1200194 반응식
Br[C:2]1([C:8]2[O:9][C:10]3[C:18]([CH2:19][C:20]#[N:21])=[CH:17][CH:16]=[CH:15][C:11]=3[C:12](=[O:14])[CH:13]=2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.[OH2:22]>>[C:2]1([C:8]2[O:9][C:10]3[C:18]([CH2:19][C:20]([NH2:21])=[O:22])=[CH:17][CH:16]=[CH:15][C:11]=3[C:12](=[O:14])[CH:13]=2)[CH2:7][CH2:6][CH2:5][CH2:4][CH:3]=1

참가 물질

3

반응물 2

HCID 962WaterHCID 146504442-(1-Bromocyclohexyl)-8-cyanomethyl-4-oxo-4H-[1]-benzopyran

생성물 1

HCID 14650455HCID 14650455, 화합물수율 57%

반응 조건

온도
120 °C

실험 절차

2-(1-Bromocyclohexyl)-8-cyanomethyl-4-oxo-4H-[1]-benzopyran (3.0 g) was added to polyphosphoric acid (120 ml) and the mixture was heated on an oil bath at about 120° C. for 2 hours. After standing overnight, water (about 300 ml) was added to decompose polyphosphoric acid. Crystals deposited were filtered off and recrystallized form the mixed solvent of dichloromethane and methanol to obtain the title compound, yield 57%.

후처리

  1. filtrationCrystals deposited were filtered off
  2. customrecrystallized form the mixed solvent of dichloromethane and methanol

출처 및 근거

ORD 기록
ord-e6c1a28b1f2b451da736b2207e9f5ead
출처 데이터셋
uspto-grants-1990_02
특허 번호
US04904690

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