Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → N-Boc-beta-alanine Propargyl Amide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Diisopropylcarbodiimide | HCID 12734 | — |
| 반응물 | N-((1,1-dimethylethoxy)carbonyl)-beta-alanine | HCID 76809 | — |
| 반응물 | Propargylamine | HCID 239041 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | N-Boc-beta-alanine Propargyl Amide | HCID 87766044 | — |
반응 단계
N-Boc-β-alanine (1a) (1.05 g, 5.5 mmol) and propargyl amine (0.90 g, 16.5 mmol) were dissolved in THF (10 mL). Diisopropyl-carbodiimide (DIC, 695 g, 5.5 mmol) was added and the reaction mixture was stirred for 16 h at room temperature. Water was added (20 mL) and the product was extracted into EtOAc (3×30 mL). The combined EtOAc was dried (Na2SO4) and evaporated. The crude product was purified by silica column chromatography eluting with EtOAc:Heptane gradient (2:3)-(3:2.5) (v/v). Product yield 0.925 g, 74%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07727713B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-81c8b3c0439348328e900f92313d677b |
| 출처 메모 | uspto-grants-2010_06 |