홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Diisopropylcarbodiimide → 3-(4,5-Dimethoxy-2-nitro benzyloxycarbonyl-amino)-butyric acid 4-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-phenyl ester

HRID 12013
노트
인쇄 미리보기

반응식

HRID 12013 반응식
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12](=[O:13])[CH:11]=[CH:10][C:9]2=[O:14])=[CH:4][CH:3]=1.[CH3:15][O:16][C:17]1[C:33]([O:34][CH3:35])=[CH:32][C:20]([CH2:21][O:22][C:23]([NH:25][CH:26]([CH3:31])[CH2:27][C:28](O)=[O:29])=[O:24])=[C:19]([N+:36]([O-:38])=[O:37])[CH:18]=1.CC(C)N=C=NC(C)C>C1COCC1>[O:13]=[C:12]1[CH:11]=[CH:10][C:9](=[O:14])[N:8]1[C:5]1[CH:4]=[CH:3][C:2]([O:1][C:28](=[O:29])[CH2:27][CH:26]([NH:25][C:23]([O:22][CH2:21][C:20]2[CH:32]=[C:33]([O:34][CH3:35])[C:17]([O:16][CH3:15])=[CH:18][C:19]=2[N+:36]([O-:38])=[O:37])=[O:24])[CH3:31])=[CH:7][CH:6]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 12734DiisopropylcarbodiimideHCID 817341-(4-hydroxyphenyl)-1H-pyrrole-2,5-dioneHCID 593366353-(4,5-Dimethoxy-2-nitro-benzyloxycarbonylamino)-butyric acid

생성물 1

HCID 593365823-(4,5-Dimethoxy-2-nitro benzyloxycarbonyl-amino)-butyric acid 4-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-phenyl ester

시약·촉매·용매 1

HCID 8028Tetrahydrofuran
용매

반응 조건

온도
0 °C

실험 절차

1-(4-Hydroxy-phenyl)-pyrrole-2,5-dione (1 mmol), NHS (1.0 mmol) and 3-(4,5-dimethoxy-2-nitro-benzyloxycarbonylamino)-butyric acid (1 mmol) is dissolved in THF (3 mL). The solution is cooled to 0° C. and treated dropwise with DIC (1.2 mmol). The cooling bath is removed after 1 hour and the reaction mixture is left at room temperature o/n. The solvent is evaporated in vacuo and the pure product (3-(4,5-dimethoxy-2-nitro benzyloxycarbonyl-amino)-butyric acid 4-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-phenyl ester) is isolated by silica column purification using EtOAc-heptane (1:4 then 1:2 then 1:1) as eluent.

후처리

  1. customThe cooling bath is removed after 1 hour
  2. waitthe reaction mixture is left at room temperature o/n
  3. customThe solvent is evaporated in vacuo

출처 및 근거

ORD 기록
ord-ef4d96badb8b48f0bcb90ff68efff15e
출처 데이터셋
uspto-grants-2010_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07727713B2

반응 노트

불러오는 중…

이 페이지에서참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트