Sulfuric Acid → 4-(4-Fluorophenyl)cyclohexan-1-one

HRID 12052노트

반응식

HRID 12052 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:17][CH2:16][C:11]3(OCC[O:12]3)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.S(=O)(=O)(O)O>O1CCOCC1>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]2[CH2:9][CH2:10][C:11](=[O:12])[CH2:16][CH2:17]2)=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 1118Sulfuric AcidHCID 128344048-(4-Fluorophenyl)-1,4-dioxaspiro[4.5]decane

생성물 1

HCID 128343224-(4-Fluorophenyl)cyclohexan-1-one

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

8-(4-fluor-phenyl)-1,4-dioxaspiro[4.5]decane (2 mmol) is dissolved in dioxane (6.5 ml) and treated with 3 ml 50% aqueous sulphuric acid accompanied by stirring at room temperature for 5 hours. After dilution with water (12 ml) extraction is carried out twice with dichloromethane. The raw title compound is obtained from the combined organic phases after drying over sodium sulphate and evaporating-off of the solvent in a vacuum (Tetrahedron 1998, 54, 15509-15524): tR 3.44 min (LC-1); ESI-MS(+): m/z 193.29 [M+H]+.

후처리

  1. extractionAfter dilution with water (12 ml) extraction

출처 및 근거

ORD 기록
ord-078b576691f14997974b7557469bacb0
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07727979B2

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