Dichloromethane → 9'-(Trifluoromethyl)-spiro[piperidine-4,6'-pyrido[2,3-b]pyrrolo[1,2-d][1,4]oxazine]

반응식

[Cl:37][CH2:38][Cl:39].[F:1][C:2]([c:3]1[cH:4][cH:5][c:6]2[n:7]1-[c:8]1[c:9]([n:24][cH:25][cH:26][cH:27]1)[O:10][C:11]21[CH2:12][CH2:13][N:14]([C:17]([O:18][C:19]([CH3:20])([CH3:21])[CH3:22])=[O:23])[CH2:15][CH2:16]1)([F:28])[F:29].[F:30][C:31]([F:32])([F:33])[C:34]([OH:35])=[O:36]>>[F:1][C:2]([c:3]1[cH:4][cH:5][c:6]2[n:7]1-[c:8]1[c:9]([n:24][cH:25][cH:26][cH:27]1)[O:10][C:11]21[CH2:12][CH2:13][NH:14][CH2:15][CH2:16]1)([F:28])[F:29]

참가 물질

반응물 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 67465074Tert-butyl 9'-(trifluoromethyl)spiro-[piperidine-4,6'-pyrido[2,3-b]pyrrolo[1,2-d][1,4]oxazine]-1-carboxylate

생성물 1

HCID 674655859'-(Trifluoromethyl)-spiro[piperidine-4,6'-pyrido[2,3-b]pyrrolo[1,2-d][1,4]oxazine]

출처 및 근거

ORD 기록: ord-d5b23ed7b0904bf3a662a48eb0018de5
출처 데이터셋: Training data from https://doi.org/10.1039/C8SC04228D (5/10)
DOI: 10.1039/C8SC04228D

반응 노트

불러오는 중…