Acetaldehyde → 4-Trifluoromethyl-7-methyl-6-ethyl-6,7,8,9-tetrahydropyrido[2,3-g]quinolin-2(1H)-one

HRID 12073

반응식

HRID 12073 반응식
[F:1][C:2]([F:24])([F:23])[C:3]1[C:16]2[C:7](=[CH:8][C:9]3[CH2:10][CH2:11][CH:12]([CH3:21])[N:13]([CH2:17][CH:18]4CC4)[C:14]=3[CH:15]=2)[NH:6][C:5](=[O:22])[CH:4]=1.C(=O)C>>[F:24][C:2]([F:1])([F:23])[C:3]1[C:16]2[C:7](=[CH:8][C:9]3[CH2:10][CH2:11][CH:12]([CH3:21])[N:13]([CH2:17][CH3:18])[C:14]=3[CH:15]=2)[NH:6][C:5](=[O:22])[CH:4]=1

참가 물질

3

반응물 2

HCID 177AcetaldehydeHCID 99675684-Trifluoromethyl-7-methyl-6-cyclopropylmethyl-6,7,8,9-tetrahydropyrido[2,3-g]quinolin-2(1H)-one

생성물 1

HCID 99012664-Trifluoromethyl-7-methyl-6-ethyl-6,7,8,9-tetrahydropyrido[2,3-g]quinolin-2(1H)-one

실험 절차

This compound was prepared in a similar fashion as that described in Example 84 from Compound 187 (Structure 33 of Scheme VI, where R1=methyl, n=1) and acetaldehyde. 1H NMR (400 MHz, CDCl3) 11.19 (br. s, 1H), 7.11 (s, 1H), 7.00 (s, 1H), 6.80 (s, 1H), 3.55 (m, 1H), 3.47-3.32 (m, 2H), 2.93-2.80 (m, 2H), 1.93-1.79 (m, 2H), 1.22 (t, 3H, J=7.0), 1.18 (d, 3H, J=6.4).

후처리

  1. customThis compound was prepared in a similar fashion as

출처 및 근거

ORD 기록
ord-c83558528a69411cbdd1d98c6c51341f
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07727980B2

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