Dichloromethane → 3-(1-Amino-2,2,2-trifluoroethyl)-5-(5-methylpyridin-2-yl)benzoic acid

반응식

[Cl:34][CH2:35][Cl:36].[NH2:1][CH:2]([C:3]([F:4])([F:5])[F:6])[c:7]1[cH:8][c:9]([C:10](=[O:11])[O:12][C:13]([CH3:14])([CH3:15])[CH3:16])[cH:17][c:18](-[c:20]2[n:21][cH:22][c:23]([CH3:26])[cH:24][cH:25]2)[cH:19]1.[OH:27][C:28]([C:29]([F:30])([F:31])[F:32])=[O:33]>>[NH2:1][CH:2]([C:3]([F:4])([F:5])[F:6])[c:7]1[cH:8][c:9]([C:10](=[O:11])[OH:12])[cH:17][c:18](-[c:20]2[n:21][cH:22][c:23]([CH3:26])[cH:24][cH:25]2)[cH:19]1

참가 물질

반응물 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 68496539Tert-butyl 3-(1-amino-2,2,2-trifluoroethyl)-5-(5-methylpyridin-2-yl)benzoate

생성물 1

HCID 685023253-(1-Amino-2,2,2-trifluoroethyl)-5-(5-methylpyridin-2-yl)benzoic acid

출처 및 근거

ORD 기록: ord-cd60d5ee4b734f96893900a25900d716
출처 데이터셋: Training data from https://doi.org/10.1039/C8SC04228D (5/10)
DOI: 10.1039/C8SC04228D

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