Dimethylamine → rac-(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-pyrrolidine-2-carboxylic acid [4-(2-dimethylamino-acetyl)-phenyl]-amide

반응식

[Br:1][CH2:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][c:8]([NH:11][C:12](=[O:13])[CH:14]2[NH:15][CH:16]([CH2:37][C:38]([CH3:39])([CH3:40])[CH3:41])[C:17]([C:27]#[N:28])([c:29]3[c:30]([F:36])[cH:31][c:32]([Cl:35])[cH:33][cH:34]3)[CH:18]2[c:19]2[c:20]([F:26])[c:21]([Cl:25])[cH:22][cH:23][cH:24]2)[cH:9][cH:10]1.[CH3:42][NH:43][CH3:44].[O:45]1[CH2:46][CH2:47][CH2:48][CH2:49]1>>[CH2:2]([C:3](=[O:4])[c:5]1[cH:6][cH:7][c:8]([NH:11][C:12](=[O:13])[CH:14]2[NH:15][CH:16]([CH2:37][C:38]([CH3:39])([CH3:40])[CH3:41])[C:17]([C:27]#[N:28])([c:29]3[c:30]([F:36])[cH:31][c:32]([Cl:35])[cH:33][cH:34]3)[CH:18]2[c:19]2[c:20]([F:26])[c:21]([Cl:25])[cH:22][cH:23][cH:24]2)[cH:9][cH:10]1)[N:43]([CH3:42])[CH3:44]