Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Citraconic Anhydrides → N-(5-bromopyridin-2-yl)-methylmaleimide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Citraconic Anhydrides | HCID 12012 | — |
| 반응물 | 2-Amino-5-bromopyridine | HCID 70622 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | N-(5-bromopyridin-2-yl)-methylmaleimide | HCID 22596423 | 71% |
반응 단계
A mixture of citraconic anhydride (1.00 mL, 11.1 mmol) and 2-amino-5-bromopyridine (1.93 g, 11.2 mmol) in toluene (60 mL) was heated to reflux overnight. The solution was cooled down, filtered. The filtrate was concentrated in vacuo to give a solid (2.10 g, yield: 71%). MS 267 and 269 (M+H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07727981B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-d06354339c1c4248aa2e70c96f4c2652 |
| 출처 메모 | uspto-grants-2010_06 |