Dichloromethane → Tert-butyl 1-(2-(2-fluoro-6-hydroxyphenyl)-7-methylquinazolin-4-yl)piperidin-4-ylcarbamate

반응식

[CH3:21][CH2:22][N:23]([CH2:24][CH3:25])[CH2:26][CH3:27].[Cl:1][c:2]1[n:3][c:4](-[c:13]2[c:14]([OH:20])[cH:15][cH:16][cH:17][c:18]2[F:19])[n:5][c:6]2[cH:7][c:8]([CH3:12])[cH:9][cH:10][c:11]12.[Cl:42][CH2:43][Cl:44].[NH:28]1[CH2:29][CH2:30][CH:31]([NH:34][C:35]([O:36][C:37]([CH3:38])([CH3:39])[CH3:40])=[O:41])[CH2:32][CH2:33]1>>[c:2]1([N:28]2[CH2:29][CH2:30][CH:31]([NH:34][C:35]([O:36][C:37]([CH3:38])([CH3:39])[CH3:40])=[O:41])[CH2:32][CH2:33]2)[n:3][c:4](-[c:13]2[c:14]([OH:20])[cH:15][cH:16][cH:17][c:18]2[F:19])[n:5][c:6]2[cH:7][c:8]([CH3:12])[cH:9][cH:10][c:11]12