Tetrahydrofuran → 2-(2,6-difluorophenyl)-4-(4-chlorophenyl)-5,6-dihydro-4H-1,3-oxazine

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[CH3:1][S:2](=[O:3])(=[O:4])[Cl:5].[CH3:28][CH2:29][N:30]([CH2:31][CH3:32])[CH2:33][CH3:34].[F:6][c:7]1[c:8]([C:9](=[O:10])[NH:11][CH:12]([CH2:13][CH2:14][OH:15])[c:16]2[cH:17][cH:18][c:19]([Cl:22])[cH:20][cH:21]2)[c:23]([F:27])[cH:24][cH:25][cH:26]1.[O:35]1[CH2:36][CH2:37][CH2:38][CH2:39]1>>[F:6][c:7]1[c:8]([C:9]2=[N:11][CH:12]([c:16]3[cH:17][cH:18][c:19]([Cl:22])[cH:20][cH:21]3)[CH2:13][CH2:14][O:15]2)[c:23]([F:27])[cH:24][cH:25][cH:26]1