Water → Tert-butyl 9'-(trifluoromethyl)spiro-[piperidine-4,6'-pyrido[2,3-b]pyrrolo[1,2-d][1,4]oxazine]-1-carboxylate

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[F:26][C:27]([s+:28]1[c:29]2[cH:30][cH:31][cH:32][cH:33][c:34]2[c:35]2[cH:36][cH:37][cH:38][cH:39][c:40]12)([F:41])[F:42].[O:44]=[CH:45][N:46]([CH3:47])[CH3:48].[OH2:43].[cH:1]1[cH:2][cH:3][n:4][c:5]2[c:22]1-[n:21]1[c:20]([cH:25][cH:24][cH:23]1)[C:7]1([O:6]2)[CH2:8][CH2:9][N:10]([C:13](=[O:14])[O:15][C:16]([CH3:17])([CH3:18])[CH3:19])[CH2:11][CH2:12]1>>[cH:1]1[cH:2][cH:3][n:4][c:5]2[c:22]1-[n:21]1[c:20]([cH:25][cH:24][c:23]1[C:27]([F:26])([F:41])[F:42])[C:7]1([O:6]2)[CH2:8][CH2:9][N:10]([C:13](=[O:14])[O:15][C:16]([CH3:17])([CH3:18])[CH3:19])[CH2:11][CH2:12]1