Dichloromethane → 1-(2-Chloro-7-methylquinazolin-4-yl)pyrrolidin-3-amine

반응식

[Cl:1][c:2]1[n:3][c:4]2[cH:5][c:6]([CH3:25])[cH:7][cH:8][c:9]2[c:10]([N:12]2[CH2:13][CH:14]([NH:17][C:18](=[O:19])[O:20][C:21]([CH3:22])([CH3:23])[CH3:24])[CH2:15][CH2:16]2)[n:11]1.[Cl:33][CH2:34][Cl:35].[OH:26][C:27]([C:28]([F:29])([F:30])[F:31])=[O:32]>>[Cl:1][c:2]1[n:3][c:4]2[cH:5][c:6]([CH3:25])[cH:7][cH:8][c:9]2[c:10]([N:12]2[CH2:13][CH:14]([NH2:17])[CH2:15][CH2:16]2)[n:11]1

참가 물질

반응물 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 72554489tert-butyl N-[1-(2-chloro-7-methylquinazolin-4-yl)pyrrolidin-3-yl]carbamate

생성물 1

HCID 725544901-(2-Chloro-7-methylquinazolin-4-yl)pyrrolidin-3-amine

출처 및 근거

ORD 기록: ord-6068b628781a45c4b5068d01159d1bd3
출처 데이터셋: Training data from https://doi.org/10.1039/C8SC04228D (2/10)
DOI: 10.1039/C8SC04228D

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