Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 12180생성일: 2026년 10월 25일
1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → N-(6-chloro-7-methoxy-9H-beta-carbolin-8-yl)-2-methylnicotinamide
https://huagongshe.com/reaction/12180
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| 반응물 | 2-Methylnicotinic acid | HCID 643373 | — |
| 반응물 | 6-Chloro-7-methoxy-9h-pyrido[3,4-b]indol-8-amine | HCID 21362743 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | N-(6-chloro-7-methoxy-9H-beta-carbolin-8-yl)-2-methylnicotinamide | HCID 9929127 | 50% |
반응 단계
6-chloro-7-methoxy-9H-β-carbolin-8-ylamine (100 mg, 0.4 mmol), EDCI (125 mg, 0.64 mmol) and 2-methyl nicotinic acid (66 mg, 0.48 mmol) were taken in a round-bottom flask and suspended in pyridine (2 ml). The resulting mixture was heated at 80° C. overnight. The pyridine was then removed by rotary evaporation and 5% Na2CO3 solution was added. The resulting solid that precipitated out was collected by filtration. Chromatographic purification gave the desired product in 50-70% yield.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07727985B2 |
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| 출처 데이터셋 | uspto-grants-2010_06 |
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| ORD ID | ord-dbeb848e8fc94ab2bca7c131609a2899 |
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| 출처 메모 | uspto-grants-2010_06 |
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