2-(4-(6-Chloro-2-methylpyrimidin-4-yl)piperazin-1-yl)ethanol → N-(3-(2-(6-(4-(2-Hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thieno[3,2-d]pyrimidin-7-yl)phenyl)methanesulfonamide

반응식

[Cl:22][c:23]1[cH:24][c:25]([N:30]2[CH2:31][CH2:32][N:33]([CH2:36][CH2:37][OH:38])[CH2:34][CH2:35]2)[n:26][c:27]([CH3:29])[n:28]1.[NH2:1][c:2]1[n:3][cH:4][c:5]2[c:6]([n:7]1)[c:8](-[c:11]1[cH:12][c:13]([NH:17][S:18](=[O:19])(=[O:20])[CH3:21])[cH:14][cH:15][cH:16]1)[cH:9][s:10]2>>[NH:1]([c:2]1[n:3][cH:4][c:5]2[c:6]([n:7]1)[c:8](-[c:11]1[cH:12][c:13]([NH:17][S:18](=[O:19])(=[O:20])[CH3:21])[cH:14][cH:15][cH:16]1)[cH:9][s:10]2)[c:23]1[cH:24][c:25]([N:30]2[CH2:31][CH2:32][N:33]([CH2:36][CH2:37][OH:38])[CH2:34][CH2:35]2)[n:26][c:27]([CH3:29])[n:28]1

참가 물질

반응물 2

HCID 144795582-(4-(6-Chloro-2-methylpyrimidin-4-yl)piperazin-1-yl)ethanol

HCID 67120132N-(3-(2-aminothieno[3,2-d]pyrimidin-7-yl)phenyl)methanesulfonamide

생성물 1

HCID 67120131N-(3-(2-(6-(4-(2-Hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thieno[3,2-d]pyrimidin-7-yl)phenyl)methanesulfonamide

출처 및 근거

ORD 기록: ord-25315d2eaa944d0789b0a22f21d3316f
출처 데이터셋: Training data from https://doi.org/10.1039/C8SC04228D (5/10)
DOI: 10.1039/C8SC04228D

반응 노트

불러오는 중…