Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethanol → Ethyl 6-chloronicotinate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 반응물 | 2-Dimethylaminopyridine | HCID 21885 | — |
| 반응물 | 6-Chloronicotinic acid | HCID 79222 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Ethyl 6-chloronicotinate | HCID 2799611 | — |
반응 단계
A mixture of 15.75 g (0.1 mol) 6-chloronicotinic acid, 6.9 g (0.15 mol) ethanol, 22.7 g (0.11 mol) dicyclohexylcarbodiimide and 3.7 g dimethylaminopyridine in 200 ml methylene chloride was heated at reflux for 2 hours. The mixture was allowed to cool, solvent removed in vacuo and the residue subjected to flash chromatography to give the title compound as a low-melting white solid. PMR (CDCl3): & 1.44 (3H, t, J~6.2 Hz) 4.44 (2H, q, J~4.4 Hz), 7.44 (1H, d, J~8.1 Hz), 8.27 (1H, dd, J~8.1 Hz, 3 Hz), 9.02 (1H, d, J~3 Hz).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05723620 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-314d43ab585348f7bd5e6d904c0e5adc |
| 출처 메모 | uspto-grants-1998_03 |