Dichloromethane → 4-[4-(3-Pyrrolidin-1-ylpropoxy)phenyl]piperidine-4-carbonitrile

반응식

[C:1](#[N:2])[C:3]1([c:16]2[cH:17][cH:18][c:19]([O:22][CH2:23][CH2:24][CH2:25][N:26]3[CH2:27][CH2:28][CH2:29][CH2:30]3)[cH:20][cH:21]2)[CH2:4][CH2:5][N:6]([C:9]([O:10][C:11]([CH3:12])([CH3:13])[CH3:14])=[O:15])[CH2:7][CH2:8]1.[Cl:38][CH2:39][Cl:40].[OH:31][C:32]([C:33]([F:34])([F:35])[F:36])=[O:37]>>[C:1](#[N:2])[C:3]1([c:16]2[cH:17][cH:18][c:19]([O:22][CH2:23][CH2:24][CH2:25][N:26]3[CH2:27][CH2:28][CH2:29][CH2:30]3)[cH:20][cH:21]2)[CH2:4][CH2:5][NH:6][CH2:7][CH2:8]1

참가 물질

반응물 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 68578770Tert-butyl 4-cyano-4-[4-(3-pyrrolidin-1-ylpropoxy)phenyl]piperidine-1-carboxylate

생성물 1

HCID 598373684-[4-(3-Pyrrolidin-1-ylpropoxy)phenyl]piperidine-4-carbonitrile

출처 및 근거

ORD 기록: ord-0af1aa050d0e4730bdd7cf4c0c530ef3
출처 데이터셋: Training data from https://doi.org/10.1039/C8SC04228D (5/10)
DOI: 10.1039/C8SC04228D

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