Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,6-Dimethylmorpholine → (3S)-N-(6-Chloro-9H-pyrido[3,4-b]indol-8-yl)-4-[2-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-2-oxoethyl]-6,6-dimethyl-3-morpholinecarboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,6-Dimethylmorpholine | HCID 110862 | — |
| 반응물 | [5-(6-Chloro-9H-beta-carbolin-8-ylcarbamoyl)-2,2-dimethyl-morpholin-4-yl]-acetic acid | HCID 59337527 | — |
| 생성물 | (3S)-N-(6-Chloro-9H-pyrido[3,4-b]indol-8-yl)-4-[2-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-2-oxoethyl]-6,6-dimethyl-3-morpholinecarboxamide | HCID 67165125 | — |
반응 단계
The desired compound was prepared using [5-(6-Chloro-9H-beta-carbolin-8-ylcarbamoyl)-2,2-dimethyl-morpholin-4-yl]-acetic acid and 2,6-dimethyl morpholine following Method F. Chromatographic purification gave the desired product in 70-80% yield.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07727985B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-497f81d843fd40b38b68639b9989b285 |
| 출처 메모 | uspto-grants-2010_06 |