Bromine → Methyl 2-amino-5-bromo-3-nitrobenzoate

HRID 12253노트

반응식

HRID 12253 반응식
[CH3:1][O:2][C:3](=[O:14])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([N+:10]([O-:12])=[O:11])[C:5]=1[NH2:13].[Br:15]Br>C(O)(=O)C>[CH3:1][O:2][C:3](=[O:14])[C:4]1[CH:9]=[C:8]([Br:15])[CH:7]=[C:6]([N+:10]([O-:12])=[O:11])[C:5]=1[NH2:13]

참가 물질

4

반응물 2

HCID 24408BromineHCID 607264Methyl 2-amino-3-nitrobenzoate

생성물 1

HCID 17984898Methyl 2-amino-5-bromo-3-nitrobenzoate수율 87.4%

시약·촉매·용매 1

HCID 176Acetic Acid용매2회

실험 절차

To a solution of 2.23 g (10.4 mmol) of 2-amino-3-nitro-benzoic acid methyl ester in 12 mL of acetic acid was added dropwise over 5 minutes a solution of 0.53 mL (10.4 mmol, 1 eq) of bromine in 2 mL of acetic acid. The mixture was stirred at room temperature for 30 minutes and poured into 100 grams of ice. The precipitated yellow solid was collected by suction filtration and dried to afford 2.50 g (82%) of the title compound as a yellow solid. 1H NMR (CDCl3) δ 3.95 (s, 3H), 8.35 (br s, 2H), 8.6 (d, 1H).

후처리

  1. filtrationThe precipitated yellow solid was collected by suction filtration
  2. customdried

출처 및 근거

ORD 기록
ord-becf597f931c48eab6d0ab9385f0ebff
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07727992B2

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