Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylformamide → 6-(2-Ethylaminopyrimidin-4-yl)-3-oxo-2,3-dihydropyridazine-4-carboxylic acid (2amino-4-chlorophenyl)amide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | 4-Chloro-1,2-diaminobenzene | HCID 7263 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 6-(2-Ethylaminopyrimidin-4-yl)-3-oxo-2,3-dihydropyridazine-4-carboxylic acid | HCID 68453325 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 6-(2-Ethylaminopyrimidin-4-yl)-3-oxo-2,3-dihydropyridazine-4-carboxylic acid (2amino-4-chlorophenyl)amide | HCID 86611604 | — |
반응 단계
A solution of 110 mg of 6-(2-ethylaminopyrimidin-4-yl)-3-oxo-2,3-dihydropyridazine-4-carboxylic acid, 2 ml of DMF and 0.17 ml of triethylamine is mixed with 192 mg of Hatu and stirred at room temperature for 30 minutes. Then 66 mg of 4-chloro-phenylenediamine are added, and the mixture is stirred at room temperature overnight. 5 ml of water are added to the mixture, and the precipitate is briefly stirred and then filtered off with suction and dried.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07727989B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-c6db62493a0541ae9904ac2a0c41fb10 |
| 출처 메모 | uspto-grants-2010_06 |