Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 12276생성일: 2026년 10월 23일
Potassium Acetate → 6-Oxo-5-[6-tri-fluoromethyl-1-(2-trimethylsilanylethoxymethyl)-1H-benzimidazol-2-yl]-1-(2-trimethylsilanylethoxymethyl)-1,6-dihydropyridazine-3-boronic acid
https://huagongshe.com/ko/reaction/12276
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Acetate | HCID 517044 | — |
| 반응물 | Bis(pinacolato)diborane | HCID 2733548 | — |
| 반응물 | 6-Chloro-4-[6-trifluormethyl-1-(2-trimethylsilanylethoxymethyl)-1h-benzimidazol-2-yl]-2-(2-trimethylsilanylethoxymethyl)-2h-pyridazin-3-one | HCID 68681137 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 생성물 | 6-Oxo-5-[6-tri-fluoromethyl-1-(2-trimethylsilanylethoxymethyl)-1H-benzimidazol-2-yl]-1-(2-trimethylsilanylethoxymethyl)-1,6-dihydropyridazine-3-boronic acid | HCID 68680596 | — |
반응 단계
6-Chloro-4-[6-trifluormethyl-1-(2-trimethylsilanylethoxymethyl)-1H-benzimidazol-2-yl]-2-(2-trimethylsilanylethoxymethyl)-2H-pyridazin-3-one (prepared in analogy to example 15b), bis(pinacolato)diboron, (1,1′-bis(diphenylphosphine)ferrocene)-palladium(II) chloride-dichloromethane complex and potassium acetate are dissolved in DMSO. The solution is degassed with argon and heated at 95° C. for 2.5 hours. The reaction solution is filtered through silica gel, and the latter is washed with dichloromethane. The solvent is removed in a rotary evaporator, and the crude product is purified by RP-HPLC (0-100% acetonitrile in water (+0.01% trifluoroacetic acid)). MS (ES+) m/z 585 (M+H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07727989B2 |
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| 출처 데이터셋 | uspto-grants-2010_06 |
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| ORD ID | ord-bb9f641574f3407fbcc52c5df3b9224e |
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| 출처 메모 | uspto-grants-2010_06 |
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