반응식
CC1(C)C2C=C(C#C[C:14]3[CH:24]=[CH:23][C:17]([C:18]([O:20][CH2:21][CH3:22])=[O:19])=[CH:16][CH:15]=3)C=CC=2C(=O)CC1.[CH:27]1([O:33][CH:34]2[C:43]3[C:38](=[CH:39][CH:40]=[C:41]([C:44]#[CH:45])[CH:42]=3)[C:37]([CH3:47])([CH3:46])[CH2:36][CH2:35]2)[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]1>>[CH:27]1([O:33][CH:34]2[CH2:35][CH2:36][C:37]([CH3:47])([CH3:46])[C:38]3[CH:39]=[CH:40][C:41]([C:44]#[C:45][C:14]4[CH:24]=[CH:23][C:17]([C:18]([O:20][CH2:21][CH3:22])=[O:19])=[CH:16][CH:15]=4)=[CH:42][C:43]2=3)[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]1참가 물질
3
실험 절차
Employing the same general procedure as for the preparation of ethyl 4-[(5,6,7,8-tetrahydro-8,8-dimethyl-5-oxonaphth-2-yl)ethynyl]benzoate (Compound 1), 90 mg (0.3 mmol) of 4-cyclohexyloxy-6-ethynyl-1,2,3,4-tetrahydro-1,1-dimethylnaphthalene (Compound N) was converted into the title compound using 88 mg (0.32 mmol) of ethyl 4-iodobenzoate, 70 mg (0.1 mmol) of bis(triphenylphosphine)palladium(II) chloride and 19 mg (0.1 mmol) of cuprous iodide.
출처 및 근거
- ORD 기록
- ord-ccf8d7ba858a4a1d98efae7e84bea37c
- 출처 데이터셋
- uspto-grants-1998_03
- 특허 번호
- US05723620
연결된 노트
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