6-Chloro-3-oxo-2,3-dihydropyridazine-4-carboxylic acid (2-amino-phenyl)amide → 4-(1H-Benzimidazol-2-yl)-6-chloro-2H-pyridazin-3-one

HRID 12283노트

반응식

HRID 12283 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9]([C:11]1[C:12](=[O:18])[NH:13][N:14]=[C:15]([Cl:17])[CH:16]=1)=O>C(O)(=O)C>[NH:8]1[C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[N:1]=[C:9]1[C:11]1[C:12](=[O:18])[NH:13][N:14]=[C:15]([Cl:17])[CH:16]=1

참가 물질

3

반응물 1

HCID 866116096-Chloro-3-oxo-2,3-dihydropyridazine-4-carboxylic acid (2-amino-phenyl)amide

생성물 1

HCID 1359787814-(1H-Benzimidazol-2-yl)-6-chloro-2H-pyridazin-3-one

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A solution of 26.4 g of 6-chloro-3-oxo-2,3-dihydropyridazine-4-carboxylic acid (2-aminophenyl)amide in 500 ml of acetic acid is stirred at 110° C. for 2.5 hours and then the solvent is distilled off. The crude product obtained in this way is employed without further purification.

후처리

  1. distillationthe solvent is distilled off

출처 및 근거

ORD 기록
ord-0a5a35357a4242119c12cf0fec91f87f
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07727989B2

반응 노트

불러오는 중…