Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 12288생성일: 2026년 10월 24일
2-Morpholinoethylamine → 6-[2-(2-Morpholin-4-ylethylamino)pyrimidin-4-yl]-2-(2-trimethylsilanyl-ethoxymethyl)-4-[1-(2-trimethylsilanylethoxymethyl)-1H-benzimidazol-2-yl]-2H-pyridazin-3-one
https://huagongshe.com/ko/reaction/12288
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 2-Morpholinoethylamine | HCID 408285 | — |
| 반응물 | 6-(2-chloropyrimidin-4-yl)-2-(2-trimethylsilanylethoxymethyl)-4-[1-(2-trimethylsilanylethoxymethyl)-1H-benzimidazol-2-yl]-2H-pyridazin-3-one | HCID 86611610 | — |
| 생성물 | 6-[2-(2-Morpholin-4-ylethylamino)pyrimidin-4-yl]-2-(2-trimethylsilanyl-ethoxymethyl)-4-[1-(2-trimethylsilanylethoxymethyl)-1H-benzimidazol-2-yl]-2H-pyridazin-3-one | HCID 68681172 | — |
반응 단계
100 mg of 6-(2-chloropyrimidin-4-yl)-2-(2-trimethylsilanylethoxymethyl)-4-[1-(2-trimethylsilanylethoxymethyl)-1H-benzimidazol-2-yl]-2H-pyridazin-3-one are suspended in 0.5 ml of N-(2-aminoethyl)morpholine, and the reaction mixture is heated at 100° C. in a microwave for 20 minutes. The product is purified by preparative RP-HPLC (0-100% acetonitrile (+0.05% formic acid) in water (+0.05% formic acid)).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07727989B2 |
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| 출처 데이터셋 | uspto-grants-2010_06 |
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| ORD ID | ord-da03c4138f9d41ce88d2d0a3dba761c6 |
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| 출처 메모 | uspto-grants-2010_06 |
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