Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Tosylmethyl isocyanide → 5-[5-Bromo-3-methoxy-2-(2-trimethylsilanylethoxymethoxy)-phenyl]oxazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Tosylmethyl isocyanide | HCID 161915 | — |
| 반응물 | 5-Bromo-3-methoxy-2-(2-trimethylsilanylethoxymethoxy)benzaldehyde | HCID 86070969 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 5-[5-Bromo-3-methoxy-2-(2-trimethylsilanylethoxymethoxy)-phenyl]oxazole | HCID 68681178 | — |
반응 단계
1 g of 5-bromo-3-methoxy-2-(2-trimethylsilanylethoxymethoxy)benzaldehyde and 0.54 g of p-toluenesulfonylmethyl isocyanide are dissolved in 40 ml of methanol, 0.38 g of o-potassiumcarbonate is added in portions, and the reaction mixture is heated to reflux for 18 h. The solvent is then distilled off, and the crude product is purified by silica gel chromatography (ethyl acetate/heptane).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07727989B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-552dac4e3cd44625bf490bacd309abfc |
| 출처 메모 | uspto-grants-2010_06 |