Tosylmethyl isocyanide → 5-[5-Bromo-3-methoxy-2-(2-trimethylsilanylethoxymethoxy)-phenyl]oxazole

HRID 12295

반응식

HRID 12295 반응식
[Br:1][C:2]1[CH:3]=[C:4]([O:19][CH3:20])[C:5]([O:10][CH2:11][O:12][CH2:13][CH2:14][Si:15]([CH3:18])([CH3:17])[CH3:16])=[C:6]([CH:9]=1)[CH:7]=[O:8].C1(C)C=CC(S([CH2:30][N+:31]#[C-:32])(=O)=O)=CC=1>CO>[Br:1][C:2]1[CH:3]=[C:4]([O:19][CH3:20])[C:5]([O:10][CH2:11][O:12][CH2:13][CH2:14][Si:15]([CH3:16])([CH3:18])[CH3:17])=[C:6]([C:7]2[O:8][CH:32]=[N:31][CH:30]=2)[CH:9]=1

참가 물질

4

반응물 2

HCID 161915Tosylmethyl isocyanideHCID 860709695-Bromo-3-methoxy-2-(2-trimethylsilanylethoxymethoxy)benzaldehyde

생성물 1

HCID 686811785-[5-Bromo-3-methoxy-2-(2-trimethylsilanylethoxymethoxy)-phenyl]oxazole

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

1 g of 5-bromo-3-methoxy-2-(2-trimethylsilanylethoxymethoxy)benzaldehyde and 0.54 g of p-toluenesulfonylmethyl isocyanide are dissolved in 40 ml of methanol, 0.38 g of o-potassiumcarbonate is added in portions, and the reaction mixture is heated to reflux for 18 h. The solvent is then distilled off, and the crude product is purified by silica gel chromatography (ethyl acetate/heptane).

후처리

  1. temperaturethe reaction mixture is heated
  2. temperatureto reflux for 18 h
  3. distillationThe solvent is then distilled off
  4. customthe crude product is purified by silica gel chromatography (ethyl acetate/heptane)

출처 및 근거

ORD 기록
ord-552dac4e3cd44625bf490bacd309abfc
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07727989B2

연결된 노트

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