(4-Chlorophenyl)acetic acid → Methyl 4-chlorophenylacetate

반응식

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=[O:10])=[CH:4][CH:3]=1.Cl.[CH3:13]O>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][C:9]([O:11][CH3:13])=[O:10])=[CH:6][CH:7]=1

참가 물질

반응물 2

HCID 15880(4-Chlorophenyl)acetic acid

HCID 21893726Hydrochloride methanol

생성물 1

HCID 104196Methyl 4-chlorophenylacetate

실험 절차

4-Chlorophenylacetic acid (5.0 g) was dissolved in 10% hydrogen chloride-methanol solution (50 ml) and heated under reflex for 14 hours. The solvent then was removed under reduced pressure and saturated sodium hydrogencarbonate solution was added to the residue, followed by extraction with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and condensed under reduced pressure to provide methyl 2-(4-chlorophenyl)acetate (5.35 g) as a colorless, oily substance.

후처리

temperatureheated under reflex for 14 hours
customThe solvent then was removed under reduced pressure and saturated sodium hydrogencarbonate solution
additionwas added to the residue
extractionfollowed by extraction with ethyl acetate
dry with materialThe organic layer was dried over anhydrous sodium sulfate and condensed under reduced pressure

출처 및 근거

ORD 기록: ord-0989b2748d704d2894e860d20aea4ea4
출처 데이터셋: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07727998B2

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