Imidazole → methyl 2-(4-chlorophenyl)-2-(1H-imidazol-1-yl)-acetate

HRID 12301

반응식

HRID 12301 반응식
[NH:1]1[CH:5]=[CH:4][N:3]=[CH:2]1.C(N(CC)CC)C.Br[CH:14]([C:19]1[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=1)[C:15]([O:17][CH3:18])=[O:16].O>CN(C=O)C>[Cl:25][C:22]1[CH:21]=[CH:20][C:19]([CH:14]([N:1]2[CH:5]=[CH:4][N:3]=[CH:2]2)[C:15]([O:17][CH3:18])=[O:16])=[CH:24][CH:23]=1

참가 물질

6

반응물 4

HCID 795ImidazoleHCID 962WaterHCID 8471TriethylamineHCID 10777987Methyl 2-bromo-2-(4-chlorophenyl)acetate

생성물 1

HCID 23092022methyl 2-(4-chlorophenyl)-2-(1H-imidazol-1-yl)-acetate수율 64%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매2회

실험 절차

To a solution of imidazole (170 mg) and triethylamine (350 ml) in DMF (1 ml), a solution of methyl 2-bromo-2-(4-chlorophenyl)-acetate (657 mg) in DMF (3 ml) was added. After stirring for an overnight, water was added to the reaction liquid, followed by extraction with ethyl acetate, washing with saturated brine and drying over anhydrous sodium sulfate. The reaction liquid was condensed under reduced pressure and the resulting residue was purified on silica gel column chromatography (methanol/chloroform=1/10) to provide methyl 2-(4-chlorophenyl)-2-(1H-imidazol-1-yl)-acetate (400 mg) as a yellow oily substance.

후처리

  1. extractionfollowed by extraction with ethyl acetate
  2. washwashing with saturated brine
  3. dry with materialdrying over anhydrous sodium sulfate
  4. customThe reaction liquid
  5. customcondensed under reduced pressure
  6. customthe resulting residue was purified on silica gel column chromatography (methanol/chloroform=1/10)

출처 및 근거

ORD 기록
ord-c5bb6ebc07cd49ad9ab13e25aeb3b07a
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07727998B2

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