4-(3-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)pyridin-2-YL)morpholine → 1-(2-Chloro-3,6-difluorobenzyl)-7-(3-fluoro-2-morpholin-4-yl-pyridin-4-yl)-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine

반응식

[Cl:1][c:2]1[c:3]([CH2:4][N:5]2[c:6]3[c:7]([n:11][cH:12][c:13]([I:15])[cH:14]3)[NH:8][CH2:9][CH2:10]2)[c:16]([F:21])[cH:17][cH:18][c:19]1[F:20].[F:22][c:23]1[c:24]([N:38]2[CH2:39][CH2:40][O:41][CH2:42][CH2:43]2)[n:25][cH:26][cH:27][c:28]1[B:29]1[O:30][C:31]([CH3:32])([CH3:33])[C:34]([CH3:35])([CH3:36])[O:37]1>>[Cl:1][c:2]1[c:3]([CH2:4][N:5]2[c:6]3[c:7]([n:11][cH:12][c:13](-[c:28]4[c:23]([F:22])[c:24]([N:38]5[CH2:39][CH2:40][O:41][CH2:42][CH2:43]5)[n:25][cH:26][cH:27]4)[cH:14]3)[NH:8][CH2:9][CH2:10]2)[c:16]([F:21])[cH:17][cH:18][c:19]1[F:20]

참가 물질

반응물 2

HCID 164142374-(3-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)pyridin-2-YL)morpholine

HCID 578858681-(2-Chloro-3,6-difluorobenzyl)-7-iodo-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine

생성물 1

HCID 578858161-(2-Chloro-3,6-difluorobenzyl)-7-(3-fluoro-2-morpholin-4-yl-pyridin-4-yl)-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine

출처 및 근거

ORD 기록: ord-492e47a5d71741ae8326f698948e8c77
출처 데이터셋: Training data from https://doi.org/10.1039/C8SC04228D (2/10)
DOI: 10.1039/C8SC04228D

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